项目名称： 大前庭导水管综合征致聋机理的生物力学研究与临床应用

项目编号： No.11472074

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 孙秀珍

作者单位： 大连医科大学

项目金额： 86万元

中文摘要： 大前庭导水管综合征（LVAS）是近年来耳科专家高度重视的耳聋致残疾病，是儿童及青少年多发且最常见的内耳疾病。目前研究认为：由于前庭导水管先天发育畸形，在后天外伤震荡等内淋巴囊压力增高作用下，其内淋巴液经前庭导水管返流入耳蜗，致使耳蜗毛细胞受损而发生不可逆性重度感音性耳聋。本项目提取内耳淋巴管系统（内淋巴囊-前庭导水管-内淋巴管-前庭-耳蜗）的解剖形态改变在颅内外环境异变激励下，该系统力学响应异常这一关键问题，应用医学与生物力学多学科交叉的方法，基于本课题组前期内耳膜迷路的有限元数值模型研究基础，建立针对前庭导水管扩张的内耳淋巴管系统生物力学研究平台，构建较完整的内耳淋巴管系统有限元数值模型，结合相关动物实验和临床病例资料，从生物力学角度揭示LVAS诱发耳聋的发病机制；加深人们对耳聋残疾致病因素新的认识，为该病医学临床防治提供理论与实践研究基础.

中文关键词： 生物力学数值模型；大前庭导水管综合征；耳聋；有限元法

英文摘要： Large vestibular aqueduct syndrome (LVAS) is a highly concerned deafness debilitating diseases in recent years , it is a most common children and young people inner ear disease. Present study suggests that vestibular aqueduct congenital malformations , trauma acquired in the lymph sac pressure increased role of shock , etc. , so that by the vestibular aqueduct in which the lymph back into the cochlea , cochlear hair cell damage resulting in the occurrence of irreversible severe flu deafness . The project to extract the inner ear lymphatic system ( the sac - vestibular aqueduct - the lymphatic vessels - vestibule - cochlea ) morphological changes in intracranial environment mutation excitation , the mechanical response of the system is abnormal the key issue , the application medicine and biomechanics multidisciplinary approach , based on preliminary research base within our group lost eardrum finite element numerical model created for inner ear lymphatic system biomechanical numerical model vestibular aqueduct expansion , combined with relevant animal experiments and clinical data , reveal biomechanical large vestibular aqueduct syndrome induced deafness pathogenesis ; deepen people with disabilities deafness new understanding of risk factors , provide the foundation for the theory and practice of clinical medicine disease prevention ; study of modern theories of deafness development of innovative , technological innovation is expected to achieve results.

英文关键词： biomechanical model;large vestibular aqueduct syndrome;deafness;finite element method