项目名称： 气道支架植入后肉芽组织增生与局部力学因素之间的相关性研究

项目编号： No.11472062

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 张治国

作者单位： 常州大学

项目金额： 82万元

中文摘要： 多数气道狭窄需要行支架植入术，但术后短期内常在支架内部或两端发生肉芽组织增生的现象，进而导致气道再狭窄，严重的甚至会威胁到患者的生命。目前对肉芽组织增生的研究主要集中在物理消除以及药物抑制方面。申请人受应力-生长关系的启发，推测气管内置支架部位的肉芽组织生长可能与局部的力学环境改变相关。为验证这一推测，本项目拟通过计算机数值仿真分析与动物实验相结合的方法，定量化的研究二者之间的关系。具体为：1）基于三维重建的方式建立人体气道狭窄的生物力学模型；2）开展气流、气管壁以及气管支架的流固耦合分析，结合临床观察数据分析肉芽组织增生与局部力学环境因素之间的关系；3）在此基础上，探索个体化气道支架的设计、优化以及实验评估的途径和方法。本项目的实施将有助于从生物力学的角度探究支架植入后肉芽组织增生的机理，并对新型气道支架的研发具有指导意义。

中文关键词： 气道再狭窄；流固耦合分析；肉芽组织增生；气管支架；应力

英文摘要： Clinical investigations show that the airway restenosis caused by the extra growth of granulation tissue inside or at both ends of the airway stent is the most troublesome complication. Current studies on growth of granulation tissue due to implanted stent focus on physical excision and drug inhibition. Inspired by the stress-growth law in biomechanics, we hypothesize that the growth of granulation tissue may be related to the local mechanical environment associated with the implanted stent. To test this hypothesis, we propose to quantitatively investigate the correlation between the local mechanical factors and the hyperplasia of granulation tissue by using physiologically near-realistic biomechanical models of human airway stenoses. Specifically, we propose to: 1) built biomechanical models of real human airway stenoses based on 3D reconstruction of CT-scanned airway images; 2) numerically simulate the fluid-structure interaction between the airflow, the airway wall and the stent, and then analyze the correlation between hyperplasia of granulation tissue and local mechanical factors by incoperating clinical data; 3) based on these, explore approaches and methods for designing, optimizing and evaluating patient-specific. Findings from this study will help understanding the mechanisms of hyperplasia of granulation tissue due to implanted airway stent from biomechanical perspective, and providing guidance in development of innovative airway stents.

英文关键词： Airway restenosis;Fluid-structure interaction;Hyperplasia of granulation tissue;Airway stent;Stress