项目名称： 基于对侧半球抵消的磁感应相位移检测脑出血的技术研究

项目编号： No.61501472

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 无线电电子学、电信技术

项目作者： 金贵

作者单位： 中国人民解放军第三军医大学

项目金额： 20万元

中文摘要： 脑出血（ICH）后血肿扩大以及术后二次出血是增加致残率和致死率的最重要因素，而目前临床上缺乏有效的脑出血早期预警和持续监护方法。磁感应相位移（MIPS）技术基于生物组织的电磁特性，具有非接触、无创伤、连续快速测量等特点，是实现脑出血监护的最佳方法之一。已有MIPS检测方法灵敏度低，对出血量的变化不敏感。鉴于ICH的病理机制以及脑结构特点，前期实验发现采用对侧半球抵消方法（CHCM）可以将MIPS检测方式的灵敏度提高一个数量级。本课题拟在已研究基础上，以电磁仿真为指导，以CHCM线圈为工具，以已建立的MIPS测量系统为平台，以动物脑出血模型为研究对象，测量出血量与MIPS之间的定量关系；通过影像学观察、颅内压监测以及对比实验等手段研究MIPS随出血量变化的规律；再通过统计分析和信号处理寻找中线移位以及颅内压突变对应的MIPS特征点。本课题研究成果有望为临床ICH的预警和监护提供一种新的方法。

中文关键词： 非接触磁感应检测；磁感应相位移；脑出血；线圈；无创检测

英文摘要： The enlargement of hematoma after intracranial hemorrhage (ICH) and recurrent hematoma after operation are the most important factors to increasing mortality and morbidity. Effective methods of continuous monitoring and early warning in ICH is lacking in clinic. Magnetic induction phase shift (MIPS) which measured by the electromagnetic properties of biological tissues is a noncontact, noninvasive, continuous and fast detection technology, and undoubtedly becomes one of the best method for ICH detection and monitoring. The existing MIPS detection mode is not sensitive to the volume change of hematoma. Given ICH physiological features and the brain structure, we found that the contra-lateral hemisphere cancellation mode can boost MIPS sensitivity more than 10 times. On the basis of our up-front work, using the electromagnetic as a guidance, the CHCM coil as a tool, the already established MIPS measurement system as a platform, and the ICH animal mode as the research object, this study is to measure the quantitative relation between the MIPS and the bleeding volume, and explain the rule of the bleeding leading to MIPS changes, via radiologic observation, intracranial pressure monitoring, and comparison measurement. At last, the MIPS feature points corresponding to the mutation of ICP and midline shift are looked for by statistical analysis and signal processing. The study results are expected to provide a new method for ICH monitoring and early warning in clinic.

英文关键词： non-contact magnetic detection;magnetic induction phase shift;intracranial hemorrhage;coil;noninvasive detection