Public research funding agencies increasingly seek to steer health research toward higher levels of translation and societal relevance. Yet it remains unclear to what extent such policy shifts are effectively implemented and reflected in funded projects and scientific outputs. This study examines evolution and changes in the orientation of health research portfolios since 2008 within European funding (Framework Programmes FP7 and Horizon 2020 funding for collaborative health research, FP-HR, and ERC Life Sciences grants), in comparison to NIH funding for collaborative research (P01, U01, and UM1). Using large-scale text analysis and supervised classification, we analyze both project descriptions and the associated scientific publications. At the project level, the EU FP-HR show pronounced shifts toward population-level, diagnostic, and health systems-oriented research, whereas investigator-driven ERC life sciences, NIH P01 and U01, display greater stability with a predominance of basic biomedical research. Publication-level analyses reveal more moderate changes, with basic biomedical research remaining a central component including in EU FP-HR, indicating partial translation of funding priorities into outputs. By jointly analyzing projects and publications, this study identifies and distinguishes between changes in funder expectations and realized research trajectories, highlighting how strategic funding shapes research portfolios within enduring epistemic and institutional constraints.

翻译：公共研究资助机构日益引导健康研究向更高水平的转化及与社会关联的方向发展。然而，此类政策转变在多大程度上被有效实施并反映在资助项目及科学产出中仍不明确。本研究考察了自2008年以来，欧洲资助（合作健康研究的框架计划FP7和地平线2020，即FP-HR，以及欧洲研究委员会生命科学基金）与美国国立卫生研究院合作研究资助（P01、U01和UM1）中健康研究组合导向的演变与变化。通过大规模文本分析和监督分类，我们分析了项目描述及其相关科学出版物。在项目层面，欧盟FP-HR呈现出向人群水平、诊断和卫生系统导向研究的显著转变，而研究者主导的欧洲研究委员会生命科学项目、美国国立卫生研究院P01和U01则表现出更大稳定性，以基础生物医学研究为主。出版物层面的分析揭示了更为温和的变化，基础生物医学研究仍为核心组成部分，包括在欧盟FP-HR中，表明资助优先事项向产出的部分转化。通过联合分析项目与出版物，本研究识别并区分了资助方期望的变化与实现的研究轨迹，突出了战略资助如何在持久的认识论和制度约束下塑造研究组合。