In this paper, we determine the largest family $\mathcal F \subset 2^{[n]}$ without $s$ pairwise disjoint sets, provided $n=ms+c$ for positive integers $m,c$, and $s \geq s_0(m, c)$. This result can be seen as a non-uniform analogue of the results on the Erd\H os Matching Conjecture in the regime when the clique is extremal.

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