Millimeter-wave human activity recognition suffers significant performance degradation when the user's orientation changes relative to the sensing system, yet collecting labeled multi-orientation data is labor-intensive and costly. To eliminate the need for exhaustive multi-orientation measured data, we develop a physics-guided simulator that synthesizes orientation-diverse wireless training data from single-orientation motion. Specifically, to suppress orientation-induced feature variations, we propose a dual-attention network that extracts activity-discriminative and orientation-robust representations from dual-link Doppler spectrograms. To bridge the simulation-to-reality gap, we introduce an adversarial unsupervised transfer learning mechanism that aligns feature distributions using only a small number of unlabeled target-domain samples. The S2M-Sense platform shows high fidelity in reproducing real-world signatures, validated against 60.48 GHz mmWave measured data with an average structural similarity index measure (SSIM) of 0.84 between simulated and measured Doppler spectrograms across all 4 activities and 4 orientations. Experimental results show that S2M-Sense achieves 88.33% recognition accuracy using only the dual-link multi-orientation simulated dataset, which improves to 95% after simulation-to-reality transfer learning with as few as 16 unlabeled measured samples. Both cases with and without transfer learning outperform state-of-the-art cross-domain sensing methods.

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