Retrieval-Augmented Language Models (RALMs) have demonstrated significant potential in knowledge-intensive tasks; however, they remain vulnerable to performance degradation when presented with irrelevant or noisy retrieved contexts. Existing approaches to enhance robustness typically operate via coarse-grained parameter updates at the layer or module level, often overlooking the inherent neuron-level sparsity of Large Language Models (LLMs). To address this limitation, we propose Neuro-RIT (Neuron-guided Robust Instruction Tuning), a novel framework that shifts the paradigm from dense adaptation to precision-driven neuron alignment. Our method explicitly disentangles neurons that are responsible for processing relevant versus irrelevant contexts using attribution-based neuron mining. Subsequently, we introduce a two-stage instruction tuning strategy that enforces a dual capability for noise robustness: achieving direct noise suppression by functionally deactivating neurons exclusive to irrelevant contexts, while simultaneously optimizing targeted layers for evidence distillation. Extensive experiments across diverse QA benchmarks demonstrate that Neuro-RIT consistently outperforms strong baselines and robustness-enhancing methods.

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