While real quantum devices have been increasingly used to conduct research focused on achieving quantum advantage or quantum utility in recent years, executing deep quantum circuits or performing quantum machine learning with large-scale data on current noisy intermediate-scale quantum devices remains challenging, making classical simulation essential for quantum machine learning research. However, such classical simulation often suffers from the cost of gradient calculations, requiring enormous memory or computational time. To address these problems, we propose a method to fuse multiple consecutive gates in each of the forward and backward paths to improve throughput by minimizing global memory accesses. As a result, we achieved approximately $20$ times throughput improvement for a Hardware-Efficient Ansatz with $12$ or more qubits, reaching over $30$ times improvement on a mid-range consumer GPU with limited memory bandwidth. By combining our proposed method with gradient checkpointing, we drastically reduced memory usage, making it possible to train a large-scale quantum machine learning model, a $20$-qubit, $1{,}000$-layer model with $60{,}000$ parameters, using $1{,}000$ samples in approximately $20$ minutes per epoch. This implies that we can train the model on large datasets, comprising tens of thousands of samples, like MNIST or CIFAR-10, within a realistic time frame (e.g., $20$ hours per epoch). Thus, our proposed method significantly accelerates such classical simulations, making a significant contribution to advancing research in quantum machine learning and variational quantum algorithms, such as verifying algorithms on large datasets or investigating learning theories of deep quantum circuits like barren plateaus.

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