In this study, we proposed a deep Swin-Vision Transformer-based transfer learning architecture for robust multi-cancer histopathological image classification. The proposed framework integrates a hierarchical Swin Transformer with ResNet50-based convolution features extraction, enabling the model to capture both long-range contextual dependencies and fine-grained local morphological patterns within histopathological images. To validate the efficiency of the proposed architecture, an extensive experiment was executed on a comprehensive multi-cancer dataset including Breast Cancer, Oral Cancer, Lung and Colon Cancer, Kidney Cancer, and Acute Lymphocytic Leukemia (ALL), including both original and segmented images were analyzed to assess model robustness across heterogeneous clinical imaging conditions. Our approach is benchmarked alongside several state-of-the-art CNN and transfer models, including DenseNet121, DenseNet201, InceptionV3, ResNet50, EfficientNetB3, multiple ViT variants, and Swin Transformer models. However, all models were trained and validated using a unified pipeline, incorporating balanced data preprocessing, transfer learning, and fine-tuning strategies. The experimental results demonstrated that our proposed architecture consistently gained superior performance, reaching 100% test accuracy for lung-colon cancer, segmented leukemia datasets, and up to 99.23% accuracy for breast cancer classification. The model also achieved near-perfect precision, f1 score, and recall, indicating highly stable scores across divers cancer types. Overall, the proposed model establishes a highly accurate, interpretable, and also robust multi-cancer classification system, demonstrating strong benchmark for future research and provides a unified comparative assessment useful for designing reliable AI-assisted histopathological diagnosis and clinical decision-making.

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