We study a class of bilevel interdiction problems in which the follower's optimization problem is computationally intractable. Motivated by network defense applications, we introduce the Randomized Max-Vertex-Coverage Interdiction (RMVCI) problem under matroid constraints. In this zero-sum Stackelberg game, the leader commits to a randomized interdiction strategy over feasible vertex subsets, while the follower, after observing the induced protection probabilities, chooses a matroid-constrained attack to maximize the expected coverage of network edges. The main challenge stems from the fact that the follower's problem is a matroid-constrained maximum vertex coverage problem and is therefore NP-hard. To address this difficulty, we first develop a general approximation framework for bilevel optimization problems with hard follower responses. The framework is based on replacing the follower's value function by a surrogate objective that approximates the follower's optimal payoff while preserving tractability of the leader's optimization problem. For the RMVCI problem, we formulate the follower's problem as an integer linear program, establish a tight integrality gap of $4/3$ for its linear relaxation, and derive a polynomial-time $4/3$-approximation algorithm via pipage rounding. We then show that a carefully designed surrogate objective admits a marginal-probability reformulation that transforms the randomized interdiction problem into a tractable optimization problem over the leader's matroid polytope. This yields a polynomial-time $2$-approximation algorithm for RMVCI under general matroid constraints. Beyond the specific application studied here, our results provide a new perspective on approximation methods for {general} bilevel optimization problems.

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