This paper presents a spatial optimization methodology that extends the Spatial Packaging of Interconnected Systems with Physical Interaction (SPI2) framework to support arbitrary, non-convex design boundaries. We introduce a smooth, differentiable inside-outside evaluation for components represented using the Maximal Disjoint Ball Decomposition (MDBD) method. The framework also incorporates center-of-gravity and moment-of-inertia calculations directly into the optimization, and provides an end-to-end computer-aided design (CAD) workflow for importing components and reconstructing the optimized assembly. The method is demonstrated on a fictional aircraft auxiliary unit. Results show that the optimizer can place multiple interconnected components within a custom geometry while simultaneously handling routing and physics-based objectives. The approach maintains geometric feasibility within numerical tolerance and illustrates the potential of MDBD-based SPI2 methods for practical engineering design applications.

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