Magnetically programmable soft elastomers enable complex shape morphing and locomotion dynamics in small scale soft robots under external magnetic fields. Benefiting from their programmed deformation and wireless actuation capabilities, magnetic soft robots have emerged as promising platforms for targeted drug delivery, especially in human gastrointestinal tract. However, achieving controlled directional liquid cargo release toward desired tissue interface while preserving the encoded shape morphing and locomotion capabilities remain a significant challenge. Here, we report a new design strategy that employs an optimized magnetization profile to enable controlled directional release of aqueous cargo without compromising shape morphing and locomotion capabilities. Magnetic soft robots with a specific spatially distributed magnetization profile allow directional alignment of the release interface with the orientation of the external magnetic field. This orientation control ensures active alignment of the release interface toward the intestinal wall prior to drug release. An interconnected microporous elastomer is embedded within the robot for aqueous cargo storage, while a thin microcrystalline wax layer seals the release opening hole to isolate the stored liquid cargo from external environment during transport. Triggered release is achieved by mechanically rupturing the wax sealing layer under a higher magnitude external magnetic field. Controlled directional flipping, locomotion, and triggered release are decoupled through external magnetic field's direction and strength. The controlled directional release strategy reported here integrates directional targeted liquid cargo release, shape morphing, and locomotion, which establishes the groundwork for target drug delivery in gastrointestinal tract applications.

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