Dualizing monotone Boolean functions (or equivalently, enumerating minimal transversals in hypergraphs) is a long-standing problem whose output-polynomial-time solvability remains open. While various special cases have been extensively studied, the state-of-the-art algorithm for the general case, due to Fredman and Khachiyan, runs in quasipolynomial time. This paper presents a subexponential-time reduction from \textsc{3SAT} to the complement of \textsc{Dual}: Given a 3CNF formula with $n$ variables, the reduction constructs hypergraphs $H$ and $L$ of total size $2^{O(n^{2/3}(\log n)^{1/3})}$ such that $L \subseteq Tr(H)$ and the formula is satisfiable if and only if $L\neq Tr(H)$, where $Tr(H)$ is the set of minimal transversals of $H$. As a consequence of this reduction, assuming the Exponential Time Hypothesis (ETH), neither \textsc{Dual} nor \textsc{Dualization} admits an algorithm running in $N^{o(\sqrt{\log N/\log\log N})}$ time, where $N$ is the input size for \textsc{Dual} and the combined input and output size for \textsc{Dualization}. In particular, \textsc{Dualization} cannot be solved in output-polynomial time under ETH.

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