The Independent Set is a well known NP-hard optimization problem. In this work, we define a fermionic generalization of the Independent Set problem and prove that the optimization problem is QMA-hard in a $k$-particle subspace using perturbative gadgets. We discuss how the Fermionic Independent Set is related to the problem of computing the minimum eigenvalue of the $k^{\text{th}}$-Laplacian of an independence complex of a vertex weighted graph. Consequently, we use the same perturbative gadget to prove QMA-hardness of the later problem resolving an open conjecture from arXiv:2311.17234 and give the first example of a natural topological data analysis problem that is QMA-hard.

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