This paper develops a physical framework for the prebiotic emergence of information and meaning. Building on Constructor Theory, we define information as a reproducible physical difference and meaning as a difference with stable functional consequences. Casimir-Lifshitz-coupled protocell clusters serve as a minimal model that exhibits reproducible attractors, ordered transitions, and autonomous task structures. We show that such clusters carry both informational states (e.g., distances, geometries, gradients) and meaningful states that regulate prebiotic tasks such as approach, exchange, or stabilization. This approach integrates physical mechanisms, computational mechanics, and early proto-semantic functions into a coherent account of information formation before biology.

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