项目名称： 利用主客体相互作用构建多功能生物活性表面

项目编号： No.21504060

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 曹利敏

作者单位： 苏州大学

项目金额： 22万元

中文摘要： 多功能生物材料在生物传感和组织工程等领域有着很重要的应用价值。生物材料的多功能性主要取决于其表面生物活性分子的构成。目前常用的固定生物活性分子的方法易造成表面性能不稳定或生物分子活性下降等问题，而主客体化学因其反应条件温和、高效的特点，在构建稳定、复杂、有序的多功能生物活性材料方面具有很大的应用潜力。本项目拟开展利用主客体相互作用在生物材料表面引入多种生物活性分子，构建多功能生物活性表面的研究。通过调节客体分子在材料表面的接枝数量以及控制不同种类生物活性分子在主体分子上的比例，利用主客体相互作用制备具有特定密度、多种生物活性分子共修饰的生物活性表面。系统研究不同种类、比例和数量的生物活性分子的修饰对材料表面功能的影响，揭示多功能生物活性表面与生物体系的作用规律，探索其在血液接触材料等方面的应用潜力。该项目的开展对多功能性生物医用材料的研究具有重要的理论意义和应用价值。

中文关键词： 表面改性；生物活性表面；多功能性；主客体化学

英文摘要： Multifunctional biomaterials are of great importance in biomedical applications such as biosensors and tissue engineering. The multifunctionality of biomaterials depends largely on the composition of bioactive molecules immobilized on the surfaces. Currently, the methods commonly used for immobilization of bioactive molecules might result in either unstable surface properties or degradation in bioactivity. Alternatively, host-guest chemistry exhibit the potential to build stable, complex and ordered bioactive surfaces with multifunctionality due to its high efficiency and mild conditions. In this project, we intend to carry out study on construction of multifunctional bioactive surfaces by introduction of various bioactive molecules via host-guest interactions. We control the surface density and type of immobilized bioactive molecules by the regulation of the amount of guest molecules on the surface and post-modification of host molecules with different bioactive molecules, respectively. Furthermore, we systematically investigate the effects of type, ratio and quantity of immobilized bioactive molecules on the surface functionality, and thus reveal the relationship between bioactive surfaces with biological system and explore the potential of applications in the field of blood contacting materials. We expect that this project can make contribution on the investigation of multifunctional biomaterials, which has important theoretical and practical value.

英文关键词： surface modification;bioactive surface;multifunctionality;host-guest chemistry