How should researchers conduct causal inference when the outcome of interest is latent and measured imperfectly by multiple indicators? We develop a general nonparametric framework for identifying and estimating average treatment effects on latent outcomes in randomized experiments. We show that latent-outcome estimation faces two distinct noncomparability challenges. First, across studies, different measurement systems may cause estimators to target different empirical quantities even when the underlying latent treatment effect is the same. Second, within a study, different indicators may have different and possibly nonlinear relationships with the same latent outcome, making them not directly comparable. To address these challenges, we propose a design-based approach built around nonparametric bridge functions. We show that these bridge functions can be characterized and identified. Estimation relies on a debiasing procedure that permits valid inference even when the bridge functions are weakly identified. Simulations demonstrate that standard methods, such as principal components analysis and inverse covariance weighting, can generate spurious cross-study differences, whereas our approach recovers comparable latent treatment effects. Overall, the framework provides both a general strategy for causal inference with latent outcomes and practical guidance for designing measurements that support identification, comparability, and efficient estimation.

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