Recent advancements in Large Language Models (LLMs) have facilitated the development of Multimodal LLMs (MLLMs). Despite their impressive capabilities, MLLMs often suffer from over-reliance on unimodal biases (e.g., language bias and vision bias), leading to incorrect answers or hallucinations in complex multimodal tasks. To investigate this issue, we propose a causal framework to interpret the biases in Visual Question Answering (VQA) problems. Within this framework, we conduct an in-depth causal analysis to assess the causal effect of these biases on MLLM predictions. Based on the analysis, we introduce 1) a novel MORE dataset with 12,000 challenging VQA instances requiring multi-hop reasoning and overcoming unimodal biases. 2) a causality-enhanced agent framework CAVE that guides models to comprehensively integrate information from different modalities and mitigate biases. Our experiments show that MLLMs perform poorly on MORE, indicating strong unimodal biases and limited semantic understanding. However, when integrated with our CAVE, promising improvements in reasoning and bias mitigation can be seen. These findings provide important insights for the development of more robust MLLMs and contribute to the broader goal of advancing multimodal AI systems capable of deeper understanding and reasoning. Our project page is at https://github.com/OpenCausaLab/MORE.

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