This paper investigates the relationship between scientific innovation in biomedical sciences and its impact on industrial activities, focusing on how the historical impact and content of scientific papers influenced future funding and innovation grant application content for small businesses. The research incorporates bibliometric analyses along with SBIR (Small Business Innovation Research) data to yield a holistic view of the science-industry interface. By evaluating the influence of scientific innovation on industry across 10,873 biomedical topics and taking into account their taxonomic relationships, we present an in-depth exploration of science-industry interactions where we quantify the temporal effects and impact latency of scientific advancements on industrial activities, spanning from 2010 to 2021. Our findings indicate that scientific progress substantially influenced industrial innovation funding and the direction of industrial innovation activities. Approximately 76% and 73% of topics showed a correlation and Granger-causality between scientific interest in papers and future funding allocations to relevant small businesses. Moreover, around 74% of topics demonstrated an association between the semantic content of scientific abstracts and future grant applications. Overall, the work contributes to a more nuanced and comprehensive understanding of the science-industry interface, opening avenues for more strategic resource allocation and policy developments aimed at fostering innovation.

翻译：本文研究了生物医学领域的科学创新对工业活动的影响关系，重点分析了科学论文的历史影响力与内容如何影响小企业未来的融资及创新资助申请内容。研究结合文献计量分析与SBIR（小企业创新研究）数据，构建了科学-工业互动关系的全景视角。通过评估科学创新对工业活动在10,873个生物医学主题上的影响，并考虑其分类学关联，我们对2010至2021年间科学进步对工业活动的时滞效应及影响潜伏期进行了深度量化分析。研究发现，科学进展显著影响了工业创新融资方向及创新活动轨迹：约76%和73%的主题分别揭示了论文中的科学兴趣与未来小企业资金配置间的相关性及格兰杰因果关系；此外，约74%的主题中科学摘要的语义内容与未来资助申请存在关联。本研究为理解科学-工业互动机制提供了更精细全面的认知框架，为优化资源配置及创新导向政策制定开辟了新路径。