Total hip arthroplasty (THA) is a widely used surgical procedure in orthopedics. For THA, it is of clinical significance to analyze the bone structure from the CT images, especially to observe the structure of the acetabulum and femoral head, before the surgical procedure. For such bone structure analyses, deep learning technologies are promising but require high-quality labeled data for the learning, while the data labeling is costly. We address this issue and propose an efficient data annotation pipeline for producing a deep learning-oriented dataset. Our pipeline consists of non-learning-based bone extraction (BE) and acetabulum and femoral head segmentation (AFS) and active-learning-based annotation refinement (AAR). For BE we use the classic graph-cut algorithm. For AFS we propose an improved algorithm, including femoral head boundary localization using first-order and second-order gradient regularization, line-based non-maximum suppression, and anatomy prior-based femoral head extraction. For AAR, we refine the algorithm-produced pseudo labels with the help of trained deep models: we measure the uncertainty based on the disagreement between the original pseudo labels and the deep model predictions, and then find out the samples with the largest uncertainty to ask for manual labeling. Using the proposed pipeline, we construct a large-scale bone structure analyses dataset from more than 300 clinical and diverse CT scans. We perform careful manual labeling for the test set of our data. We then benchmark multiple state-of-the art deep learning-based methods of medical image segmentation using the training and test sets of our data. The extensive experimental results validate the efficacy of the proposed data annotation pipeline. The dataset, related codes and models will be publicly available at https://github.com/hitachinsk/THA.

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