Trajectory prediction is central to the safe and seamless operation of autonomous vehicles (AVs). In deployment, however, prediction models inevitably face distribution shifts between training data and real-world conditions, where rare or underrepresented traffic scenarios induce out-of-distribution (OOD) cases. While most prior OOD detection research in AVs has concentrated on computer vision tasks such as object detection and segmentation, trajectory-level OOD detection remains largely underexplored. A recent study formulated this problem as a quickest change detection (QCD) task, providing formal guarantees on the trade-off between detection delay and false alarms [1]. Building on this foundation, we propose a new framework that introduces adaptive mechanisms to achieve robust detection in complex driving environments. Empirical analysis across multiple real-world datasets reveals that prediction errors -- even on in-distribution samples -- exhibit mode-dependent distributions that evolve over time with dataset-specific dynamics. By explicitly modeling these error modes, our method achieves substantial improvements in both detection delay and false alarm rates. Comprehensive experiments on established trajectory prediction benchmarks show that our framework significantly outperforms prior UQ- and vision-based OOD approaches in both accuracy and computational efficiency, offering a practical path toward reliable, driving-aware autonomy.

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